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Clopidogrel generic vs plavix rosuvastatin) and a randomized trial comparing plavix vs rivaroxaban (Xarelto) (see Table for Key Results). The meta-analysis was conducted using bibliographic information from MEDLINE, EMBASE, Cochrane, and Psychinfo databases. Studies with a total of 34,922 subjects were included in the meta-analysis. For meta-analysis, risk of bias was assessed using the Cochrane best drugstore eye primer australia risk of bias tool, and the risk ratio with 95% confidence interval for the intervention (the number needed to treat) for the primary outcome was calculated. Results The search strategy identified 26,631 articles (Figure 1). After eliminating duplicates, 6,622 studies were included in the study. After exclusions, 8 randomized controlled trials (RCTs) (Table 1) of the treatment patients with ST-segment elevation myocardial infarction, acute secondary to left ventricular dysfunction, and nonfatal ST-segment elevation, were included in the meta-analysis. Efficacy Results Two RCTs assessing the effectiveness of plavix compared with rosuvastatin, in patients ST-segment elevation, were included. The first RCT, which was performed Clopidogrel genericon 75 mg filmtabletten in Finland by Näätänen et al, in which the combination of plavix plus rivaroxaban was compared with plavix plus fluvastatin, the effectiveness of plavix plus rivaroxaban with that of plavix alone (RR = 0.76, 95% CI, 0.47-1.10, n = 1,008 patients). A second RCT, which was performed in Malaysia by Tan et al, in which the combination of plavix plus fluvastatin was compared with plavix plus rosuvastatin, the effectiveness of plavix plus rosuvastatin with that of plavix plus fluvastatin (RR = 0.67, 95% CI, 0.38-1.12, n = 1,008 patients). Risk of Bias and Type II Errors The risk of bias was assessed using the Cochrane risk of bias tool. There were no significant differences in study quality between the 2 RCTs (Table 2). risk of bias for the outcome infarction was higher for the combined treatment of plavix plus fluvastatin than for the combined treatment of plavix plus rosuvastatin (RR = 1.40, 95% CI, 1.10-1.85, n = 1,006 patients), but this finding was not significant (P =.08). The findings for risk of bias were similar for RCTs of the treatment patients with ST-segment elevation secondary to left ventricular dysfunction and those of patients with nonfatal ST-segment elevation (Table 2). The risk of bias for outcome nonfatal MI was slightly larger for the combined treatment of plavix plus fluvastatin, but this finding was not significant (P =.13). The results regarding risk of bias for the outcome nonfatal MI were similar for the combined treatment of rosuvastatin with or without plavix (RR = 1.46, 95% CI, 0.94-2.41, n = 1,006 patients) compared with rosuvastatin alone (RR = 1.14, 95% CI, 0.70-1.84, n = 1,006 patients). There was a higher risk of bias in the rosuvastatin-trimethoprim-sulfamethoxazole combination than rosuvastatin monotherapy (RR = 1.23, 95% CI, 0.94-1.54, n = 1,006 patients). In combination with rivaroxaban, the results were similar (RR = 1.06, 95% CI, 0.67-1.66, n = 1,006 patients) and similar to the results for treatment of patients with nonfatal ST-or MI (RR = 1.07, 95% CI, 0.78-1.45, n = 1,006 patients). There was no significant difference in the results regarding risk of bias for the results treatment of patients with acute ST-segment elevation or secondary to left ventricular dysfunction (RR = 1.11, 95% CI, 0.72-1.69, n = 1,006 patients). Discussion We identified 8 RCTs evaluating the effectiveness of plavix, plavix plus rivaroxaban, and clopidogrel zentiva uk combination therapy of plavix with fluvastatin in the treatment of patients with.

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